I see on their website that the bodies are available in 40mm or 45mm diameters. I haven't personally had the manifold off my M42, so I have no idea of the stock intake port bore size.
That being said, I'd suggest running four individual bores of a smaller diameter each, over two larger bores feeding a pair of cylinders. The reason I say this is because using four throttle bodies would naturally isolate the pulsations from each intake bore (especially beneficial when running large duration cams).
If you use only two bodies feeding two bores each, the pulsations will negatively interfere with each other on the intake stroke. There are ways to design around this, but it's much easier to simply run one throttle body per cylinder.
Another thing to consider: What engine management are you going to run these throttle bodies on? If you plan to run the stock fuel injection, then you might want to reconsider, as this will be a very high cost for little to no benefit. In-fact, you'd probably loose low-end torque, and gain little top-end.
Do you have any cylinder head modifications?
Now, I believe there's a good thread on here regarding ITB's on the M42. If I recall correctly, it's been shown that expensive intake modifications are of little gain unless the head is worked accordingly. I'll see if I can find the thread to reference it.
All that being said, I'm new to these motors, so take my comments with a grain of salt.
it would use a custom manifold where the runners would be paired up. 1 tb for 2 cylinders. 2 50mm tb's would be more than enough to feed 4cylinders. and the tb's have a standoff machined into the base. you could do a dual stage injector setup.