Hi
I'd run it with a very dilute solution 5 % of vinegar for a couple of days, then check the rust. Once the rust is gone flush everything a lot and refil with grasshopper juice/water. U must get the vinegar out completely it will eat the engine if you don't. Can't stress that enough though.
Not going to cause major issues obviously a past owner didn't use coolant, grasshopper juice! But it will eventually cause problems with clogging things, radiator, thermostat etc.
Cheers Rohan